What's up?

What	What happened? What has happened? What's happening here? What's going to happen? What in the world's come over you? What about it? What's up? What if? What? What What? What color is it? What time are we talking about? What would you like? What about food? What about work? What's best for you? What's your problem? What's that got to do with me? What made you do it? What now? What's the nicest thing anybody ever did for you? -What a wonderful world it is...
When	When did it happen? When did you hear that? When was that? When did they arrive? When did you leave? When did you get back home? When were you born? When was he/she born? When would you like to eat? When will you pick me/us up? When can you/they come? When would be convenient for you? When do they/you usually close? When was the last time? When was the last time anybody gave you a great big hug? When are you going to grow up? When did you make the appointment for? When were you admitted? When did you join? When did you last kiss her/him?
Where	Where do you/they live? Where do you/they come from? Where are you/they from? Where's your/his/her/their home? Where did she/he come from? Where did they/you come from? Where would be convenient for you? Where were you/they? Where was he/she? Where did it happen? Where does it hurt? Where is what? Where are you? Where are you/they going? Where does this fit in? Where is a suitable place? Where would you like me to hit you? You mean from where I stand?
Who	Who are you? Who is that? Who was it? Who are you seeing? Who are you/they dating? Who'll pick you up? Who did it? Who's done it? Who's driving? Who took you there? Who's going to pay for it/that? Who is it going to be? Who is it for? Who's the beneficiary? Who's at fault here? Who's right and who's wrong? Who talked you/him/her/them into this? Who are you doing this for? Who is to blame for all this? Who pulled the plug? Who tapped that wire last night?
Why	Why did you/she/he/they do it? Why can't you/they/he/she listen? Why is that? Why can't I/you do the right thing? Why aren't you listening to me? Why don't you/they listen? Why couldn't you/he/she/they? Why won't you? Why would you do that? Why did she/he/they go there? Why would anybody want to go to all this trouble? Why bother? Why care? Why give a shit? Why did you set me up? Why did you fail the test? Why stay up late? Why stay onboard when the water is gone?
How	How are you doing? How's life? How's your wife? How come? How did he/she/they do it? How could she/he/they manage to do that? How small is it? How much is it? How much of a problem is it? How do you feel about it? How are you doing moneywise/financially? How would you like your steak done? How about? How about letting me in on it? How badly are you hurt? How did you get there? How about a cup of coffee? How about another round? How's life treating you old friend? How could anybody find anything in here?